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Mice deficient in thiamine have reduced glutathione levels (hence increased lipid peroxidation) and antioxidant enzymes glutathione peroxidase, SOD, catalase, glutathione reductase and glutathione transferase, as well as increased levels of OS markers, including malondialdehyde

In brief, inhibition of TrxR augments the susceptibility of tumor cells to oxidative stress, bolsters the selective eradication of cancerous cells, and instigates the cascade of apoptosis, which has received widespread attention in recent years making TrxR a potential target for cancer therapy (191, 192)

Future efforts should therefore concentrate on identifying potent, selective GR inhibitors, elucidating their mechanisms, and affirming their effectiveness and safety in preclinical studies

Underwood, 2015